Ontology highlight
ABSTRACT:
SUBMITTER: Lui AJ
PROVIDER: S-EPMC5530765 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Lui Asona J AJ Geanes Eric S ES Ogony Joshua J Behbod Fariba F Marquess Jordan J Valdez Kelli K Jewell William W Tawfik Ossama O Lewis-Wambi Joan J
Cancer letters 20170412
Interferon induced transmembrane protein 1 (IFITM1) belongs to a family of interferon stimulated genes (ISGs) that is associated with tumor progression and DNA damage resistance; however, its role in endocrine resistance is not known. Here, we correlate IFITM1 expression with clinical stage and poor response to endocrine therapy in a tissue microarray consisting of 94 estrogen receptor (ER)-positive breast tumors. IFITM1 overexpression is confirmed in the AI-resistant MCF-7:5C cell line and not ...[more]