Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury.
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ABSTRACT:
SUBMITTER: Perez EJ
PROVIDER: S-EPMC5531405 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
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Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury.
Perez Enmanuel J EJ Tapanes Stephen A SA Loris Zachary B ZB Balu Darrick T DT Sick Thomas J TJ Coyle Joseph T JT Liebl Daniel J DJ
The Journal of clinical investigation 20170717 8
After traumatic brain injury (TBI), glial cells have both beneficial and deleterious roles in injury progression and recovery. However, few studies have examined the influence of reactive astrocytes in the tripartite synapse following TBI. Here, we have demonstrated that hippocampal synaptic damage caused by controlled cortical impact (CCI) injury in mice results in a switch from neuronal to astrocytic d-serine release. Under nonpathological conditions, d-serine functions as a neurotransmitter a ...[more]
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