Ontology highlight
ABSTRACT:
SUBMITTER: Miles LA
PROVIDER: S-EPMC5531414 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20170626 8
Seneca Valley virus (SVV) is an oncolytic picornavirus with selective tropism for neuroendocrine cancers. It has shown promise as a cancer therapeutic in preclinical studies and early-phase clinical trials. Here, we have identified anthrax toxin receptor 1 (ANTXR1) as the receptor for SVV using genome-wide loss-of-function screens. ANTXR1 is necessary for permissivity in vitro and in vivo. However, robust SVV replication requires an additional innate immune defect. We found that SVV interacts di ...[more]