Ontology highlight
ABSTRACT:
SUBMITTER: Collier S
PROVIDER: S-EPMC5532237 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Collier Sharon S Paschke Peggy P Kay Robert R RR Bretschneider Till T
Scientific reports 20170727 1
Cells often employ fast, pressure-driven blebs to move through tissues or against mechanical resistance, but how bleb sites are selected and directed to the cell front remains an open question. Previously, we found that chemotaxing Dictyostelium cells preferentially bleb from concave regions, where membrane tension facilitates membrane-cortex detachment. Now, through a novel modeling approach based on actual cell contours, we use cell geometry to predict where blebs will form in migrating cells. ...[more]