Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia.
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ABSTRACT:
SUBMITTER: Tong M
PROVIDER: S-EPMC5532246 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
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Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia.
Tong Mancy M Cheng Shi-Bin SB Chen Qi Q DeSousa Joana J Stone Peter R PR James Joanna L JL Chamley Lawrence W LW Sharma Surendra S
Scientific reports 20170727 1
In preeclampsia, the serum levels of transthyretin, a carrier protein for thyroxine, are elevated. Transthyretin isolated from preeclamptic serum is also aggregated and can induce preeclampsia-like symptoms in pregnant IL10<sup>-/-</sup> mice. Using western blotting, immunofluorescence, ELISA and qRT-PCR, we investigated the production of transthyretin by preeclamptic placentae and whether transthyretin is carried into the maternal circulation via placental extracellular vesicles. Both total and ...[more]
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