Biochemical profiling of diabetes disease progression by multivariate vibrational microspectroscopy of the pancreas.
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ABSTRACT:
SUBMITTER: Nord C
PROVIDER: S-EPMC5532280 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
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Biochemical profiling of diabetes disease progression by multivariate vibrational microspectroscopy of the pancreas.
Nord Christoffer C Eriksson Maria M Dicker Andrea A Eriksson Anna A Grong Eivind E Ilegems Erwin E Mårvik Ronald R Kulseng Bård B Berggren Per-Olof PO Gorzsás András A Ahlgren Ulf U
Scientific reports 20170727 1
Despite the dramatic increase in the prevalence of diabetes, techniques for in situ studies of the underlying pancreatic biochemistry are lacking. Such methods would facilitate obtaining mechanistic understanding of diabetes pathophysiology and aid in prognostic and/or diagnostic assessments. In this report we demonstrate how a multivariate imaging approach (orthogonal projections to latent structures - discriminant analysis) can be applied to generate full vibrational microspectroscopic profile ...[more]
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