Ontology highlight
ABSTRACT:
SUBMITTER: Xin LT
PROVIDER: S-EPMC5532659 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Xin Lan-Ting LT Liu Lu L Shao Chang-Lun CL Yu Ri-Lei RL Chen Fang-Ling FL Yue Shi-Jun SJ Wang Mei M Guo Zhong-Long ZL Fan Ya-Chu YC Guan Hua-Shi HS Wang Chang-Yun CY
Marine drugs 20170709 7
Currently, DNA topoisomerase I (Topo I) inhibitors constitute a family of antitumor agents with demonstrated clinical effects on human malignancies. However, the clinical uses of these agents have been greatly limited due to their severe toxic effects. Therefore, it is urgent to find and develop novel low toxic Topo I inhibitors. In recent years, during our ongoing research on natural antitumor products, a collection of low cytotoxic or non-cytotoxic compounds with various structures were identi ...[more]