Engineered Regulatory Systems Modulate Gene Expression of Human Commensals in the Gut.
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ABSTRACT:
SUBMITTER: Lim B
PROVIDER: S-EPMC5532740 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Engineered Regulatory Systems Modulate Gene Expression of Human Commensals in the Gut.
Lim Bentley B Zimmermann Michael M Barry Natasha A NA Goodman Andrew L AL
Cell 20170401 3
The gut microbiota is implicated in numerous aspects of health and disease, but dissecting these connections is challenging because genetic tools for gut anaerobes are limited. Inducible promoters are particularly valuable tools because these platforms allow real-time analysis of the contribution of microbiome gene products to community assembly, host physiology, and disease. We developed a panel of tunable expression platforms for the prominent genus Bacteroides in which gene expression is cont ...[more]
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