Dataset Information

Differential role of CSF fatty acid binding protein 3, ?-synuclein, and Alzheimer's disease core biomarkers in Lewy body disorders and Alzheimer's dementia.

ABSTRACT:

Background

Neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease with dementia (PDD), and dementia with Lewy bodies (DLB) share clinical and molecular features. Cerebrospinal fluid (CSF) biomarkers may help the characterization of these diseases, improving the differential diagnosis. We evaluated the diagnostic performance of five CSF biomarkers across a well-characterized cohort of patients diagnosed with AD, DLB, PDD, and Parkinson's disease (PD).

Methods

A total of 208 patients were enrolled in 3 European centers. The diagnostic groups (AD, n?=?48; DLB, n?=?40; PDD, n?=?20; PD, n?=?54) were compared with cognitively healthy neurological control subjects (patients with other neurological diseases [OND], n?=?46). CSF levels of fatty acid binding protein 3, heart type (FABP3), ?-synuclein (?-syn), amyloid-? peptide 1-42, total tau (t-tau), and phosphorylated tau 181 (p-tau) were assessed with immunoassays. Univariate and multivariate statistical analyses were applied to calculate the diagnostic value of the biomarkers as well as their association with clinical scores.

Results

FABP3 levels were significantly increased in patients with AD and DLB compared with those with PD and OND (p?ConclusionsThe combination of CSF biomarkers linked to different aspects of neurodegeneration, such as FABP3, ?-syn, and AD biomarkers, improves the biochemical characterization of AD and Lewy body disorders.

SUBMITTER: Chiasserini D

PROVIDER: S-EPMC5532764 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Publications

Differential role of CSF fatty acid binding protein 3, α-synuclein, and Alzheimer's disease core biomarkers in Lewy body disorders and Alzheimer's dementia.

Chiasserini Davide D Biscetti Leonardo L Eusebi Paolo P Salvadori Nicola N Frattini Giulia G Simoni Simone S De Roeck Naomi N Tambasco Nicola N Stoops Erik E Vanderstichele Hugo H Engelborghs Sebastiaan S Mollenhauer Brit B Calabresi Paolo P Parnetti Lucilla L

Alzheimer's research & therapy 20170728 1

<h4>Background</h4>Neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease with dementia (PDD), and dementia with Lewy bodies (DLB) share clinical and molecular features. Cerebrospinal fluid (CSF) biomarkers may help the characterization of these diseases, improving the differential diagnosis. We evaluated the diagnostic performance of five CSF biomarkers across a well-characterized cohort of patients diagnosed with AD, DLB, PDD, and Parkinson's disease (PD).<h4>Methods ...[more]

PMID: 28750675

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