Ontology highlight
ABSTRACT:
SUBMITTER: Yang L
PROVIDER: S-EPMC5533100 | biostudies-literature | 2015 Jan-Mar
REPOSITORIES: biostudies-literature
Yang Lei L Ni Li L Duan Quanlu Q Wang Xingxu X Chen Chen C Chen Song S Chaugai Sandip S Zeldin D C DC Tang Jia Rong JR Wang Dao Wen DW
Prostaglandins & other lipid mediators 20150101
Cytochrome P450 epoxygenase (CYP450)-derived epoxyeicosatrienoic acids (EETs) are important regulators of cardiac remodeling; but the underlying mechanism remains unclear. The present study aimed to elucidate how EETs regulated cardiac fibrosis in response to isoprenaline (Iso) or angiotensin (Ang) II. Cardiac-specific human CYP2J2 transgenic mice (Tr) and wild-type (WT) C57BL/6 littermates were infused with Iso- or Ang II. Two weeks after infusion, Tr mice showed more alleviative cardiac fibros ...[more]