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The house spider genome reveals an ancient whole-genome duplication during arachnid evolution.


ABSTRACT: BACKGROUND:The duplication of genes can occur through various mechanisms and is thought to make a major contribution to the evolutionary diversification of organisms. There is increasing evidence for a large-scale duplication of genes in some chelicerate lineages including two rounds of whole genome duplication (WGD) in horseshoe crabs. To investigate this further, we sequenced and analyzed the genome of the common house spider Parasteatoda tepidariorum. RESULTS:We found pervasive duplication of both coding and non-coding genes in this spider, including two clusters of Hox genes. Analysis of synteny conservation across the P. tepidariorum genome suggests that there has been an ancient WGD in spiders. Comparison with the genomes of other chelicerates, including that of the newly sequenced bark scorpion Centruroides sculpturatus, suggests that this event occurred in the common ancestor of spiders and scorpions, and is probably independent of the WGDs in horseshoe crabs. Furthermore, characterization of the sequence and expression of the Hox paralogs in P. tepidariorum suggests that many have been subject to neo-functionalization and/or sub-functionalization since their duplication. CONCLUSIONS:Our results reveal that spiders and scorpions are likely the descendants of a polyploid ancestor that lived more than 450 MYA. Given the extensive morphological diversity and ecological adaptations found among these animals, rivaling those of vertebrates, our study of the ancient WGD event in Arachnopulmonata provides a new comparative platform to explore common and divergent evolutionary outcomes of polyploidization events across eukaryotes.

SUBMITTER: Schwager EE 

PROVIDER: S-EPMC5535294 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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The house spider genome reveals an ancient whole-genome duplication during arachnid evolution.

Schwager Evelyn E EE   Sharma Prashant P PP   Clarke Thomas T   Leite Daniel J DJ   Wierschin Torsten T   Pechmann Matthias M   Akiyama-Oda Yasuko Y   Esposito Lauren L   Bechsgaard Jesper J   Bilde Trine T   Buffry Alexandra D AD   Chao Hsu H   Dinh Huyen H   Doddapaneni HarshaVardhan H   Dugan Shannon S   Eibner Cornelius C   Extavour Cassandra G CG   Funch Peter P   Garb Jessica J   Gonzalez Luis B LB   Gonzalez Vanessa L VL   Griffiths-Jones Sam S   Han Yi Y   Hayashi Cheryl C   Hilbrant Maarten M   Hughes Daniel S T DST   Janssen Ralf R   Lee Sandra L SL   Maeso Ignacio I   Murali Shwetha C SC   Muzny Donna M DM   Nunes da Fonseca Rodrigo R   Paese Christian L B CLB   Qu Jiaxin J   Ronshaugen Matthew M   Schomburg Christoph C   Schönauer Anna A   Stollewerk Angelika A   Torres-Oliva Montserrat M   Turetzek Natascha N   Vanthournout Bram B   Werren John H JH   Wolff Carsten C   Worley Kim C KC   Bucher Gregor G   Gibbs Richard A RA   Coddington Jonathan J   Oda Hiroki H   Stanke Mario M   Ayoub Nadia A NA   Prpic Nikola-Michael NM   Flot Jean-François JF   Posnien Nico N   Richards Stephen S   McGregor Alistair P AP  

BMC biology 20170731 1


<h4>Background</h4>The duplication of genes can occur through various mechanisms and is thought to make a major contribution to the evolutionary diversification of organisms. There is increasing evidence for a large-scale duplication of genes in some chelicerate lineages including two rounds of whole genome duplication (WGD) in horseshoe crabs. To investigate this further, we sequenced and analyzed the genome of the common house spider Parasteatoda tepidariorum.<h4>Results</h4>We found pervasive  ...[more]

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