Dataset Information

Walking-Related Dual-Task Interference in Early-to-Middle-Stage Huntington's Disease: An Auditory Event Related Potential Study.

ABSTRACT: Objective: To compare interference between walking and a simple P3 auditory odd-ball paradigm in patients with Huntington's disease (HD) and age- and sex-matched controls. Methods: Twenty-four early-to-middle-stage HD patients and 14 age- and sex-matched healthy volunteers were examined. EEG-EMG recordings were obtained from 21 scalp electrodes and eight bipolar derivations from the legs. Principal component analysis was used to obtain artifact-free recordings. The stimulation paradigm consisted of 50 rare and 150 frequent stimuli and was performed in two conditions: standing and walking along a 10 by 5 m path. P3 wave amplitude and latency and EEG and EMG spectral values were compared by group and experimental condition and correlated with clinical features of HD. Results: P3 amplitude increased during walking in both HD patients and controls. This effect was inversely correlated with motor impairment in HD patients, who showed a beta-band power increase over the parieto-occipital regions in the walking condition during the P3 task. Walking speed and counting of rare stimuli were not compromised by concurrence of motor and cognitive demands. Conclusion: Our results showed that walking increased P3 amplitude in an auditory task, in both HD patients and controls. Concurrent cognitive and motor stimulation could be used for rehabilitative purposes as a means of enhancing activation of cortical compensatory reserves, counteracting potential negative interference and promoting the integration of neuronal circuits serving different functions.

SUBMITTER: de Tommaso M

PROVIDER: S-EPMC5535504 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Walking-Related Dual-Task Interference in Early-to-Middle-Stage Huntington's Disease: An Auditory Event Related Potential Study.

de Tommaso Marina M Ricci Katia K Montemurno Anna A Vecchio Eleonora E Invitto Sara S

Frontiers in psychology 20170731

<b>Objective:</b> To compare interference between walking and a simple P3 auditory odd-ball paradigm in patients with Huntington's disease (HD) and age- and sex-matched controls. <b>Methods:</b> Twenty-four early-to-middle-stage HD patients and 14 age- and sex-matched healthy volunteers were examined. EEG-EMG recordings were obtained from 21 scalp electrodes and eight bipolar derivations from the legs. Principal component analysis was used to obtain artifact-free recordings. The stimulation para ...[more]

PMID: 28824485

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Project description:Prior research suggests that event-related potentials (ERP) obtained during active and passive auditory paradigms, which have demonstrated abnormal neurocognitive function in schizophrenia, may provide helpful tools in predicting transition to psychosis. In addition to ERP measures, reduced modulations of EEG alpha, reflecting top-down control required to inhibit irrelevant information, have revealed attentional deficits in schizophrenia and its prodromal stage. Employing a three-stimulus novelty oddball task, nose-referenced 48-channel ERPs were recorded from 22 clinical high-risk (CHR) patients and 20 healthy controls detecting target tones (12% probability, 500Hz; button press) among nontargets (76%, 350Hz) and novel sounds (12%). After current source density (CSD) transformation of EEG epochs (-200 to 1000ms), event-related spectral perturbations were obtained for each site up to 30Hz and 800ms after stimulus onset, and simplified by unrestricted time-frequency (TF) principal components analysis (PCA). Alpha event-related desynchronization (ERD) as measured by TF factor 610-9 (spectral peak latency at 610ms and 9Hz; 31.9% variance) was prominent over right posterior regions for targets, and markedly reduced in CHR patients compared to controls, particularly in three patients who later developed psychosis. In contrast, low-frequency event-related synchronization (ERS) distinctly linked to novels (260-1; 16.0%; mid-frontal) and N1 sink across conditions (130-1; 3.4%; centro-temporoparietal) did not differ between groups. Analogous time-domain CSD-ERP measures (temporal PCA), consisting of N1 sink, novelty mismatch negativity (MMN), novelty vertex source, novelty P3, P3b, and frontal response negativity, were robust and closely comparable between groups. Novelty MMN at FCz was, however, absent in the three converters. In agreement with prior findings, alpha ERD and MMN may hold particular promise for predicting transition to psychosis among CHR patients.

Dataset Information

Walking-Related Dual-Task Interference in Early-to-Middle-Stage Huntington's Disease: An Auditory Event Related Potential Study.

Publications

Walking-Related Dual-Task Interference in Early-to-Middle-Stage Huntington's Disease: An Auditory Event Related Potential Study.

Similar Datasets

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