Mitochondrial Oxidative Stress Promotes Atherosclerosis and Neutrophil Extracellular Traps in Aged Mice.

ABSTRACT:

Rationale

Mitochondrial oxidative stress (mitoOS) has been shown to be increased in various cell types in human atherosclerosis and with aging. However, the role of cell type-specific mitoOS in atherosclerosis in the setting of advanced age and the molecular mechanisms remains to be determined in vivo.

Objective

The aim of this study was to examine the role of myeloid cell mitoOS in atherosclerosis in aged mice.

Approach and results

Lethally irradiated low-density lipoprotein receptor-deficient mice (Ldlr^-/-) were reconstituted with bone marrow from either wild-type or mitochondrial catalase (mCAT) mice. mCAT transgenic mice contain ectopically expressed human catalase gene in mitochondria, which reduces mitoOS. Starting at the age of 36 weeks, mice

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5535797 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature