Ontology highlight
ABSTRACT:
SUBMITTER: Boutin JA
PROVIDER: S-EPMC5535840 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20170623 7
The search for melatonin receptor agonists and antagonists specific towards one of the receptor subtypes will extend our understanding of the role of this system in relaying circadian information to the body. A series of compounds derived from a hit compound discovered in a screening process led to powerful agonists specific for one of the isoform of the melatonin receptor namely, MT₂. The compounds are based on a poorly explored skeleton in the molecular pharmacology of melatonin. By changing t ...[more]