Ontology highlight
ABSTRACT:
SUBMITTER: Gebura K
PROVIDER: S-EPMC5535923 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Gębura Katarzyna K Świerkot Jerzy J Wysoczańska Barbara B Korman Lucyna L Nowak Beata B Wiland Piotr P Bogunia-Kubik Katarzyna K
International journal of molecular sciences 20170704 7
Genes involved in regulation of the nuclear factor-κB (NF-κB)-pathway are suggested to play a role in pathogenesis of rheumatoid arthritis (RA). In the present study, genetic polymorphisms of <i>TLR2</i>, <i>TLR4</i>, <i>TLR9</i> and <i>NF-κB1</i> genes were investigated to assess their associations with RA susceptibility, progression and response to anti-TNF-α therapy. A group of 110 RA patients and 126 healthy individuals were genotyped for <i>TLR2</i> (rs111200466), <i>TLR4</i> (rs4986790, rs ...[more]