Ontology highlight
ABSTRACT:
SUBMITTER: Chugh P
PROVIDER: S-EPMC5536221 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Chugh Priyamvada P Clark Andrew G AG Smith Matthew B MB Cassani Davide A D DAD Dierkes Kai K Ragab Anan A Roux Philippe P PP Charras Guillaume G Salbreux Guillaume G Paluch Ewa K EK
Nature cell biology 20170522 6
Animal cell shape is largely determined by the cortex, a thin actin network underlying the plasma membrane in which myosin-driven stresses generate contractile tension. Tension gradients result in local contractions and drive cell deformations. Previous cortical tension regulation studies have focused on myosin motors. Here, we show that cortical actin network architecture is equally important. First, we observe that actin cortex thickness and tension are inversely correlated during cell-cycle p ...[more]