Genetic polymorphisms associated with heart failure: A literature review.
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ABSTRACT:
SUBMITTER: Guo M
PROVIDER: S-EPMC5536573 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Genetic polymorphisms associated with heart failure: A literature review.
Guo Mengqi M Guo Guanlun G Ji Xiaoping X
The Journal of international medical research 20160114 1
<h4>Objective</h4>To review possible associations reported between genetic variants and the risk, therapeutic response and prognosis of heart failure.<h4>Methods</h4>Electronic databases (PubMed, Web of Science and CNKI) were systematically searched for relevant papers, published between January 1995 and February 2015.<h4>Results</h4>Eighty-two articles covering 29 genes and 39 polymorphisms were identified.<h4>Conclusion</h4>Genetic association studies of heart failure have been highly controve ...[more]
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Project description:Background and objectivesNew treatments and interventions are in development to address clinical needs in heart failure. To support decision making on reimbursement, cost-effectiveness analyses are frequently required. A systematic literature review was conducted to identify and summarize heart failure utility values for use in economic evaluations.MethodsDatabases were searched for articles published until June 2019 that reported health utility values for patients with heart failure. Publications were reviewed with specific attention to study design; reported values were categorized according to the health states, 'chronic heart failure', 'hospitalized', and 'other acute heart failure'. Interquartile limits (25th percentile 'Q1', 75th percentile 'Q3') were calculated for health states and heart failure subgroups where there were sufficient data.ResultsThe systematic literature review identified 161 publications based on data from 142 studies. Utility values for chronic heart failure were reported by 128 publications; 39 publications published values for hospitalized and three for other acute heart failure. There was substantial heterogeneity in the specifics of the study populations, methods of elicitation, and summary statistics, which is reflected in the wide range of utility values reported. EQ-5D was the most used instrument; the interquartile limit for mean EQ-5D values for chronic heart failure was 0.64-0.72.ConclusionsThere is a wealth of published utility values for heart failure to support economic evaluations. Data are heterogenous owing to specificities of the study population and methodology of utility value elicitation and analysis. Choice of value(s) to support economic models must be carefully justified to ensure a robust economic analysis.
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