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Magnetic resonance imaging of local and remote vascular remodelling after experimental stroke.

ABSTRACT: The pattern of vascular remodelling in relation to recovery after stroke remains largely unclear. We used steady-state contrast-enhanced magnetic resonance imaging to assess the development of cerebral blood volume and microvascular density in perilesional and exofocal areas from (sub)acutely to chronically after transient stroke in rats. Microvascular density was verified histologically after infusion with Evans Blue dye. At day 1, microvascular cerebral blood volume and microvascular density were reduced in and around the ischemic lesion (intralesional borderzone: microvascular cerebral blood volume?=?72?±?8%; microvascular density?=?76?±?8%) (P?

SUBMITTER: Yanev P

PROVIDER: S-EPMC5536787 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Magnetic resonance imaging of local and remote vascular remodelling after experimental stroke.

Yanev Pavel P Seevinck Peter R PR Rudrapatna Umesh S US Bouts Mark Jrj MJ van der Toorn Annette A Gertz Karen K Kronenberg Golo G Endres Matthias M van Tilborg Geralda A GA Dijkhuizen Rick M RM

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20160101 8

The pattern of vascular remodelling in relation to recovery after stroke remains largely unclear. We used steady-state contrast-enhanced magnetic resonance imaging to assess the development of cerebral blood volume and microvascular density in perilesional and exofocal areas from (sub)acutely to chronically after transient stroke in rats. Microvascular density was verified histologically after infusion with Evans Blue dye. At day 1, microvascular cerebral blood volume and microvascular density w ...[more]

PMID: 27798270

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Remote scanning support in magnetic resonance imaging: Friend or foe?

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