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Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated Fusarium solani infection.

ABSTRACT: Disseminated Fusarium infection is associated with high mortality in immunocompromised patients. Patients with acute myeloid leukemia (AML) often have an extended duration of neutropenia during intensive induction chemotherapy, consolidation chemotherapy, and hematopoietic stem cell transplantation (SCT). There is no consensus regarding management of invasive disseminated Fusarium infections in the setting of prolonged neutropenia (Tortorano et al., 2014) [1]. We report a case of disseminated Fusarium in a patient with relapsed AML who underwent successful chemotherapy and haplo-identical allogeneic SCT with administration of granulocyte colony stimulating factor (G-CSF) and granulocyte infusions.

SUBMITTER: Sheela S 

PROVIDER: S-EPMC5536877 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated <i>Fusarium solani</i> infection.

Sheela Sheenu S   Ito Sawa S   Strich Jeffrey R JR   Manion Maura M   Montemayor-Garcia Celina C   Wang Hao-Wei HW   Oetjen Karolyn A KA   West Kamile A KA   Barrett Austin J AJ   Parta Mark M   Gea-Banacloche Juan J   Holland Steven M SM   Hourigan Christopher S CS   Lai Catherine C  

Leukemia research reports 20170718

Disseminated <i>Fusarium</i> infection is associated with high mortality in immunocompromised patients. Patients with acute myeloid leukemia (AML) often have an extended duration of neutropenia during intensive induction chemotherapy, consolidation chemotherapy, and hematopoietic stem cell transplantation (SCT). There is no consensus regarding management of invasive disseminated <i>Fusarium</i> infections in the setting of prolonged neutropenia (Tortorano et al., 2014) [1]. We report a case of d  ...[more]

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