Heritable and acquired disorders of phosphate metabolism: Etiologies involving FGF23 and current therapeutics.
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ABSTRACT:
SUBMITTER: Clinkenbeard EL
PROVIDER: S-EPMC5537045 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Heritable and acquired disorders of phosphate metabolism: Etiologies involving FGF23 and current therapeutics.
Clinkenbeard Erica L EL White Kenneth E KE
Bone 20170131
Phosphate is critical for many cellular processes and structural functions, including as a key molecule for nucleic acid synthesis and energy metabolism, as well as hydroxyapatite formation in bone. Therefore it is critical to maintain tight regulation of systemic phosphate levels. Based upon its broad biological importance, disruption of normal phosphate homeostasis has detrimental effects on skeletal integrity and overall health. Investigating heritable diseases of altered phosphate metabolism ...[more]
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