Ontology highlight
ABSTRACT:
SUBMITTER: Toscano MG
PROVIDER: S-EPMC5537168 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Toscano Miguel G MG van der Velden Jeroen J van der Werf Sybrand S Odijk Machteld M Roque Ana A Camacho-Garcia Rafael J RJ Herrera-Gomez Irene G IG Mancini Irene I de Haan Peter P
Molecular therapy. Methods & clinical development 20170705
Replication-defective (RD) recombinant simian virus 40 (SV40)-based gene delivery vectors hold a great potential for clinical applications because of their presumed non-immunogenicity and capacity to induce immune tolerance to the transgene products in humans. However, the clinical use of SV40 vectors has been hampered by the lack of a packaging cell line that produces replication-competent (RC) free SV40 particles in the vector production process. To solve this problem, we have adapted the curr ...[more]