Ontology highlight
ABSTRACT:
SUBMITTER: Schaar K
PROVIDER: S-EPMC5537171 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Schaar Katrin K Geisler Anja A Kraus Milena M Pinkert Sandra S Pryshliak Markian M Spencer Jacqueline F JF Tollefson Ann E AE Ying Baoling B Kurreck Jens J Wold William S WS Klopfleisch Robert R Toth Karoly K Fechner Henry H
Molecular therapy. Nucleic acids 20170708
Infections of immunocompromised patients with human adenoviruses (hAd) can develop into life-threatening conditions, whereas drugs with anti-adenoviral efficiency are not clinically approved and have limited efficacy. Small double-stranded RNAs that induce RNAi represent a new class of promising anti-adenoviral therapeutics. However, as yet, their efficiency to treat hAd5 infections has only been investigated in vitro. In this study, we analyzed artificial microRNAs (amiRs) delivered by self-com ...[more]