Ontology highlight
ABSTRACT:
SUBMITTER: Vitale G
PROVIDER: S-EPMC5537710 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Vitale Giovanni G Dicitore Alessandra A Pepe Daniele D Gentilini Davide D Grassi Elisa S ES Borghi Maria O MO Gelmini Giulia G Cantone Maria C MC Gaudenzi Germano G Misso Gabriella G Di Blasio Anna M AM Hofland Leo J LJ Caraglia Michele M Persani Luca L
Molecular oncology 20170621 8
Medullary thyroid cancer (MTC) is a tumor highly resistant to chemo- and radiotherapy. Drug resistance can be induced by epigenetic changes such as aberrant DNA methylation. To overcome drug resistance, we explored a promising approach based on the use of 5-aza-2'-deoxycytidine (AZA), a demethylating agent, in combination with the mTOR inhibitor everolimus in MTC cells (MZ-CRC-1 and TT). This combined treatment showed a strong synergistic antiproliferative activity through the induction of apopt ...[more]