Ontology highlight
ABSTRACT:
SUBMITTER: Goffredo M
PROVIDER: S-EPMC5537762 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Goffredo Martina M Santoro Nicola N Tricò Domenico D Giannini Cosimo C D'Adamo Ebe E Zhao Hongyu H Peng Gang G Yu Xiaoqing X Lam Tukiet T TT Pierpont Bridget B Caprio Sonia S Herzog Raimund I RI
Nutrients 20170622 7
Dysregulation of several metabolite pathways, including branched-chain amino acids (BCAAs), are associated with Non-Alcoholic Fatty Liver Disease (NAFLD) and insulin resistance in adults, while studies in youth reported conflicting results. We explored whether, independently of obesity and insulin resistance, obese adolescents with NAFLD display a metabolomic signature consistent with disturbances in amino acid and lipid metabolism. A total of 180 plasma metabolites were measured by a targeted m ...[more]