Ontology highlight
ABSTRACT:
SUBMITTER: Nghiem P
PROVIDER: S-EPMC55378 | biostudies-literature | 2001 Jul
REPOSITORIES: biostudies-literature
Nghiem P P Park P K PK Kim Y Y Vaziri C C Schreiber S L SL
Proceedings of the National Academy of Sciences of the United States of America 20010701 16
Premature chromatin condensation (PCC) is a hallmark of mammalian cells that begin mitosis before completing DNA replication. This lethal event is prevented by a highly conserved checkpoint involving an unknown, caffeine-sensitive mediator. Here, we have examined the possible involvement of the caffeine-sensitive ATM and ATR protein kinases in this checkpoint. We show that caffeine's ability to inhibit ATR (but not ATM) causes PCC, that ATR (but not ATM) prevents PCC, and that ATR prevents PCC v ...[more]