Mutations and mechanisms in congenital and age-related cataracts.
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ABSTRACT:
SUBMITTER: Shiels A
PROVIDER: S-EPMC5538314 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
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Mutations and mechanisms in congenital and age-related cataracts.
Shiels Alan A Hejtmancik J Fielding JF Hejtmancik J Fielding JF
Experimental eye research 20160619
The crystalline lens plays an important role in the refractive vision of vertebrates by facilitating variable fine focusing of light onto the retina. Loss of lens transparency, or cataract, is a frequently acquired cause of visual impairment in adults and may also present during childhood. Genetic studies have identified mutations in over 30 causative genes for congenital or other early-onset forms of cataract as well as several gene variants associated with age-related cataract. However, the pa ...[more]
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