Dataset Information

Central noradrenaline transporter availability in highly obese, non-depressed individuals.

ABSTRACT: The brain noradrenaline (NA) system plays an important role in the central nervous control of energy balance and is thus implicated in the pathogenesis of obesity. The specific processes modulated by this neurotransmitter which lead to obesity and overeating are still a matter of debate.We tested the hypothesis that in vivo NA transporter (NAT) availability is changed in obesity by using positron emission tomography (PET) and S,S-[11C]O-methylreboxetine (MRB) in twenty subjects comprising ten highly obese (body mass index BMI?>?35 kg/m2), metabolically healthy, non-depressed individuals and ten non-obese (BMI?

SUBMITTER: Hesse S

PROVIDER: S-EPMC5538358 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Central noradrenaline transporter availability in highly obese, non-depressed individuals.

Hesse Swen S Becker Georg-Alexander GA Rullmann Michael M Bresch Anke A Luthardt Julia J Hankir Mohammed K MK Zientek Franziska F Reißig Georg G Patt Marianne M Arelin Katrin K Lobsien Donald D Müller Ulrich U Baldofski S S Meyer Philipp M PM Blüher Matthias M Fasshauer Mathias M Fenske Wiebke K WK Stumvoll Michael M Hilbert Anja A Ding Yu-Shin YS Sabri Osama O

European journal of nuclear medicine and molecular imaging 20170109 6

<h4>Purpose</h4>The brain noradrenaline (NA) system plays an important role in the central nervous control of energy balance and is thus implicated in the pathogenesis of obesity. The specific processes modulated by this neurotransmitter which lead to obesity and overeating are still a matter of debate.<h4>Methods</h4>We tested the hypothesis that in vivo NA transporter (NAT) availability is changed in obesity by using positron emission tomography (PET) and S,S-[<sup>11</sup>C]O-methylreboxetine ...[more]

PMID: 28066877

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Project description:BackgroundAlterations of hypothalamic-pituitary-adrenal (HPA) axis activity and serotonergic signaling are implicated in the pathogenesis of human obesity and may contribute to its metabolic and mental complications. The association of these systems has not been investigated in human obesity.ObjectiveTo investigate the relation of HPA responsiveness and serotonin transporter (5-HTT) availability in otherwise healthy individuals with obesity class II or III (OB) compared to non-obesity controls (NO).Study participantsTwenty-eight OB (21 females; age 36.6 ± 10.6 years; body mass index (BMI) 41.2 ± 5.1 kg/m2) were compared to 12 healthy NO (8 females; age 35.8 ± 7.4 years; BMI 22.4 ± 2.3 kg/m2), matched for age and sex.MethodsHPA axis responsiveness was investigated using the combined dexamethasone/corticotropin-releasing hormone (dex/CRH) test, and curve indicators were derived for cortisol and adrenocorticotropic hormone (ACTH). The 5-HTT selective tracer [11C]DASB was applied, and parametric images of the binding potentials (BPND) were calculated using the multilinear reference tissue model and evaluated by atlas-based volume of interest (VOI) analysis. The self-questionnaires of behavioral inhibition system/behavioral activation system (BIS/BAS) with subscales drive, fun-seeking and reward were assessed.ResultsOB showed significant positive correlations of ACTH curve parameters with overall 5-HTT BPND (ACTHAUC: r = 0.39, p = 0.04) and 5-HTT BPND of the caudate nucleus (ACTHAUC: r = 0.54, p = 0.003). In NO, cortisol indicators correlated significantly with BPND in the hippocampus (cortisolAUC: r = 0.59, p = 0.04). In OB, BAS reward was inversely associated with the ACTHAUC (r = -0.49, p = 0.009).ConclusionThe present study supports a serotonergic-neuroendocrine association, which regionally differs between OB and NO. In OB, areas processing emotion and reward seem to be in-volved. The finding of a serotonergic HPA correlation may have implications for other diseases with dysregulated stress axis responsiveness, and for potential pharmacologic interven-tions.

Dataset Information

Central noradrenaline transporter availability in highly obese, non-depressed individuals.

Publications

Central noradrenaline transporter availability in highly obese, non-depressed individuals.

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