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Multiplexed Point-of-Care Testing - xPOCT.

ABSTRACT: Multiplexed point-of-care testing (xPOCT), which is simultaneous on-site detection of different analytes from a single specimen, has recently gained increasing importance for clinical diagnostics, with emerging applications in resource-limited settings (such as in the developing world, in doctors' offices, or directly at home). Nevertheless, only single-analyte approaches are typically considered as the major paradigm in many reviews of point-of-care testing. Here, we comprehensively review the present diagnostic systems and techniques for xPOCT applications. Different multiplexing technologies (e.g., bead- or array-based systems) are considered along with their detection methods (e.g., electrochemical or optical). We also address the unmet needs and challenges of xPOCT. Finally, we critically summarize the in-field applicability and the future perspectives of the presented approaches.

SUBMITTER: Dincer C

PROVIDER: S-EPMC5538621 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Multiplexed Point-of-Care Testing - xPOCT.

Dincer Can C Bruch Richard R Kling André A Dittrich Petra S PS Urban Gerald A GA

Trends in biotechnology 20170426 8

Multiplexed point-of-care testing (xPOCT), which is simultaneous on-site detection of different analytes from a single specimen, has recently gained increasing importance for clinical diagnostics, with emerging applications in resource-limited settings (such as in the developing world, in doctors' offices, or directly at home). Nevertheless, only single-analyte approaches are typically considered as the major paradigm in many reviews of point-of-care testing. Here, we comprehensively review the ...[more]

PMID: 28456344

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