Gray-matter relationships to diagnostic and transdiagnostic features of drug and behavioral addictions.

ABSTRACT: Alterations in neural structure have been reported in both cocaine-use disorder and gambling disorder, separately, suggesting similarities across addiction diagnoses. Individual variation in neural structure has also been associated with impulsivity, a dimensional construct implicated in addictions. This study combines categorical (diagnosis-based) and dimensional (transdiagnostic) approaches to identify neural structural alterations linked to addiction subtypes and trait impulsivity, respectively, across individuals with gambling disorder (n = 35), individuals with cocaine-use disorder (n = 37) and healthy comparison individuals (n = 37). High-resolution T1-weighted data were analyzed using modulated voxel-based morphometry (VBM). Statistical analyses were conducted using whole-brain gene

SUBMITTER: Yip SW 

PROVIDER: S-EPMC5538947 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature