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Metabonomics Approach to Assessing the Modulatory Effects of Kisspeptin-10 on Liver Injury Induced by Heat Stress in Rats.


ABSTRACT: The protective effects of Kisspeptin on heat-induced oxidative stress in rats were investigated by using a combination of biochemical parameters and metabonomics. Metabonomic analyses were performed using gas chromatography/mass spectrometry in conjunction with multivariate and univariate statistical analyses. At the end point of the heat stress experiment, histological observation, ultrastructural analysis and biochemical parameters were measured. Metabonomic analysis of liver tissue revealed that Kisspeptin mainly attenuated the alteration of purine metabolism and fatty acid metabolism pathways. Futhermore, Kisspeptin also increased the levels of GSH, T-AOC as well as SOD activities, and upregulated MDA levels. These results provide important mechanistic insights into the protective effects of Kisspeptin against heat-induced oxidative stress.

SUBMITTER: Hou Y 

PROVIDER: S-EPMC5539146 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Metabonomics Approach to Assessing the Modulatory Effects of Kisspeptin-10 on Liver Injury Induced by Heat Stress in Rats.

Hou Yuanlong Y   Wang Xiaoyan X   Ping Jihui J   Lei Zhihai Z   Gao Yingdong Y   Ma Zhiyu Z   Jia Cuicui C   Zhang Zheng Z   Li Xiang X   Jin Mengmeng M   Li Xiaoliang X   Suo Chuan C   Zhang Ying Y   Su Juan J  

Scientific reports 20170801 1


The protective effects of Kisspeptin on heat-induced oxidative stress in rats were investigated by using a combination of biochemical parameters and metabonomics. Metabonomic analyses were performed using gas chromatography/mass spectrometry in conjunction with multivariate and univariate statistical analyses. At the end point of the heat stress experiment, histological observation, ultrastructural analysis and biochemical parameters were measured. Metabonomic analysis of liver tissue revealed t  ...[more]

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