CACNA1C polymorphisms Impact Cognitive Recovery in Patients with Bipolar Disorder in a Six-week Open-label Trial.
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ABSTRACT:
SUBMITTER: Lin K
PROVIDER: S-EPMC5539285 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
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CACNA1C polymorphisms Impact Cognitive Recovery in Patients with Bipolar Disorder in a Six-week Open-label Trial.
Lin Kangguang K Xu Guiyun G Shi Lingling L Lu Weicong W Guan Lijie L Ouyang Huiyi H Chen Kun K Dang Yamei Y Zhou Libing L So Kwok-Fai KF
Scientific reports 20170801 1
Cognitive impairments in bipolar patients deteriorate as the disorder progresses. Little is known about whether genetic risks impact cognitive recovery during the course from depression to remission. In this six-week open-label trial, we shed light on the impacts of six single nucleotide polymorphisms (SNPs) in the calcium voltage-gated channel subunit alpha1 C (CACNA1C) gene on cognitive recovery in 192 bipolar patients suffering a major depressive episode (MDE). The primary outcome measures we ...[more]
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