Assessment of genetic polymorphisms associated with hyperuricemia or gout in the Hmong.
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ABSTRACT:
SUBMITTER: Roman YM
PROVIDER: S-EPMC5539965 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Assessment of genetic polymorphisms associated with hyperuricemia or gout in the Hmong.
Roman Youssef M YM Culhane-Pera Kathleen A KA Menk Jeremiah J Straka Robert J RJ
Personalized medicine 20160801 5
<h4>Aim</h4>Hyperuricemia commonly causes gout. Minnesota Hmong exhibit a two- to fivefold higher prevalence of gout versus non-Hmong. To elucidate a possible genomic contribution to this disparity, prevalence of risk alleles for hyperuricemia in Hmong was compared with European (CEU) and Han-Chinese (CHB).<h4>Methods</h4>In total, 235 Hmong were genotyped for eight SNPs representing five candidate genes (<i>SLC22A12</i>, <i>SLC2A9</i>, <i>ABCG2</i>, <i>SLC17A1</i> and <i>PDZK1</i>).<h4>Results< ...[more]
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