Metabolic anticipation in Mycobacterium tuberculosis.
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ABSTRACT:
SUBMITTER: Eoh H
PROVIDER: S-EPMC5540153 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Metabolic anticipation in Mycobacterium tuberculosis.
Eoh Hyungjin H Wang Zhe Z Layre Emilie E Rath Poonam P Morris Roxanne R Branch Moody D D Rhee Kyu Y KY
Nature microbiology 20170522
Humans serve as both host and reservoir for Mycobacterium tuberculosis, making tuberculosis a theoretically eradicable disease. How M. tuberculosis alternates between host-imposed quiescence and sporadic bouts of replication to complete its life cycle, however, remains unknown. Here, we identify a metabolic adaptation that is triggered upon entry into hypoxia-induced quiescence but facilitates subsequent cell cycle re-entry. Catabolic remodelling of the cell surface trehalose mycolates of M. tub ...[more]
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