Disentangling PTEN-cooperating tumor suppressor gene networks in cancer.
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ABSTRACT:
SUBMITTER: de la Rosa J
PROVIDER: S-EPMC5540202 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Disentangling <i>PTEN</i>-cooperating tumor suppressor gene networks in cancer.
de la Rosa Jorge J Weber Julia J Rad Roland R Bradley Allan A Cadiñanos Juan J
Molecular & cellular oncology 20170504 4
We have recently performed a whole-body, genome-wide screen in mice using a single-copy inactivating transposon for the identification of <i>Pten</i> (phosphatase and tensin homolog)-cooperating tumor suppressor genes (TSGs). We identified known and putative TSGs in multiple cancer types and validated the functional and clinical relevance of several promising candidates for human prostate cancer. ...[more]
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