Ontology highlight
ABSTRACT:
SUBMITTER: Kulkarni S
PROVIDER: S-EPMC5540287 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Kulkarni Shubhankar S Sharda Sakshi S Watve Milind M
PloS one 20170802 8
Type 2 diabetes mellitus (T2DM) is believed to be irreversible although no component of the pathophysiology is irreversible. We show here with a network model that the apparent irreversibility is contributed by the structure of the network of inter-organ signalling. A network model comprising all known inter-organ signals in T2DM showed bi-stability with one insulin sensitive and one insulin resistant attractor. The bi-stability was made robust by multiple positive feedback loops suggesting an e ...[more]