Ontology highlight
ABSTRACT:
SUBMITTER: Fenouille N
PROVIDER: S-EPMC5540325 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Fenouille Nina N Bassil Christopher F CF Ben-Sahra Issam I Benajiba Lina L Alexe Gabriela G Ramos Azucena A Pikman Yana Y Conway Amy S AS Burgess Michael R MR Li Qing Q Luciano Frédéric F Auberger Patrick P Galinsky Ilene I DeAngelo Daniel J DJ Stone Richard M RM Zhang Yi Y Perkins Archibald S AS Shannon Kevin K Hemann Michael T MT Puissant Alexandre A Stegmaier Kimberly K
Nature medicine 20170213 3
Expression of the MECOM (also known as EVI1) proto-oncogene is deregulated by chromosomal translocations in some cases of acute myeloid leukemia (AML) and is associated with poor clinical outcome. Here, through transcriptomic and metabolomic profiling of hematopoietic cells, we reveal that EVI1 overexpression alters cellular metabolism. A screen using pooled short hairpin RNAs (shRNAs) identified the ATP-buffering, mitochondrial creatine kinase CKMT1 as necessary for survival of EVI1-expressing ...[more]