Ontology highlight
ABSTRACT:
SUBMITTER: Cai TT
PROVIDER: S-EPMC5540616 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Cai Ting-Ting TT Ye Shu-Biao SB Liu Yi-Na YN He Jia J Chen Qiu-Yan QY Mai Hai-Qiang HQ Zhang Chuan-Xia CX Cui Jun J Zhang Xiao-Shi XS Busson Pierre P Zeng Yi-Xin YX Li Jiang J Li Jiang J
PLoS pathogens 20170721 7
Myeloid-derived suppressor cells (MDSCs) are expanded in tumor microenvironments, including that of Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC). The link between MDSC expansion and EBV infection in NPC is unclear. Here, we show that EBV latent membrane protein 1 (LMP1) promotes MDSC expansion in the tumor microenvironment by promoting extra-mitochondrial glycolysis in malignant cells, which is a scenario for immune escape initially suggested by the frequent, concomitant de ...[more]