Ontology highlight
ABSTRACT:
SUBMITTER: Valle-Orero J
PROVIDER: S-EPMC5540753 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Valle-Orero Jessica J Rivas-Pardo Jaime Andrés JA Tapia-Rojo Rafael R Popa Ionel I Echelman Daniel J DJ Haldar Shubhasis S Fernández Julio M JM
Angewandte Chemie (International ed. in English) 20170519 33
A hallmark of tissue ageing is the irreversible oxidative modification of its proteins. We show that single proteins, kept unfolded and extended by a mechanical force, undergo accelerated ageing in times scales of minutes to days. A protein forced to be continuously unfolded completely loses its ability to contract by folding, becoming a labile polymer. Ageing rates vary among different proteins, but in all cases they lose their mechanical integrity. Random oxidative modification of cryptic side ...[more]