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Epigenetics and Oxidative Stress in Aging.

ABSTRACT: Aging is a multifactorial process characterized by the progressive loss of physiological functions, leading to an increased vulnerability to age-associated diseases and finally to death. Several theories have been proposed to explain the nature of aging. One of the most known identifies the free radicals produced by the mitochondrial metabolism as the cause of cellular and DNA damage. However, there are also several evidences supporting that epigenetic modifications, such as DNA methylation, noncoding RNAs, and histone modifications, play a critical role in the molecular mechanism of aging. In this review, we explore the significance of these findings and argue how the interlinked effects of oxidative stress and epigenetics can explain the cause of age-related declines.

SUBMITTER: Guillaumet-Adkins A

PROVIDER: S-EPMC5541801 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Epigenetics and Oxidative Stress in Aging.

Guillaumet-Adkins Amy A Yañez Yania Y Peris-Diaz Manuel D MD Calabria Ines I Palanca-Ballester Cora C Sandoval Juan J

Oxidative medicine and cellular longevity 20170720

Aging is a multifactorial process characterized by the progressive loss of physiological functions, leading to an increased vulnerability to age-associated diseases and finally to death. Several theories have been proposed to explain the nature of aging. One of the most known identifies the free radicals produced by the mitochondrial metabolism as the cause of cellular and DNA damage. However, there are also several evidences supporting that epigenetic modifications, such as DNA methylation, non ...[more]

PMID: 28808499

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