Ontology highlight
ABSTRACT:
SUBMITTER: Rincon E
PROVIDER: S-EPMC5542197 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Rincón Esther E Cejalvo Teresa T Kanojia Deepak D Alfranca Arantzazu A Rodríguez-Milla Miguel Ángel MÁ Gil Hoyos Raul Andrés RA Han Yu Y Zhang Lingjiao L Alemany Ramón R Lesniak Maciej S MS García-Castro Javier J
Oncotarget 20170701 28
Oncolytic virotherapy represents a promising alternative for cancer treatment; however, viral delivery to the tumor represents a major challenge. Mesenchymal stem cells (MSCs) chemotax to tumors, and can serve as a viral delivery tool. Previously, we demonstrated antitumor therapeutic efficacy for mesenchymal stem cells (MSCs) infected with the oncolytic human adenovirus ICOVIR5 (Celyvir) for treatment of neuroblastoma patients. Given the lack of suitable immunocompetent preclinical models, the ...[more]