Ontology highlight
ABSTRACT:
SUBMITTER: Kießling MK
PROVIDER: S-EPMC5542218 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Kießling Michael K MK Nicolay Jan P JP Schlör Tabea T Klemke Claus-Detlev CD Süss Dorothee D Krammer Peter H PH Gülow Karsten K
Oncotarget 20170701 28
Therapy of cutaneous T cell lymphoma (CTCL) is complicated by a distinct resistance of the malignant T cells towards apoptosis that can be caused by NRAS mutations in late-stage patients. These mutations correlate with decreased overall survival, but sensitize the respective CTCL cells towards MEK-inhibition-induced apoptosis which represents a promising novel therapeutic target in CTCL. Here, we show that the multi-kinase inhibitor Sorafenib induces apoptosis in NRAS-mutated CTCL cells. CTCL ce ...[more]