Ontology highlight
ABSTRACT:
SUBMITTER: Lee SH
PROVIDER: S-EPMC5542239 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Lee Soo Hyun SH Kim Jung-Sun JS Zheng Siyuan S Huse Jason T JT Bae Joon Seol JS Lee Ji Won JW Yoo Keon Hee KH Koo Hong Hoe HH Kyung Sungkyu S Park Woong-Yang WY Sung Ki W KW
Oncotarget 20170701 28
Targeted panel sequencing was performed to determine molecular targets and biomarkers in 72 children with neuroblastoma. Frequent genetic alterations were detected in ALK (16.7%), BRCA1 (13.9%), ATM (12.5%), and PTCH1 (11.1%) in an 83-gene panel. Molecular targets for targeted therapy were identified in 16 of 72 patients (22.2%). Two-thirds of ALK mutations were known to increase sensitivity to ALK inhibitors. Sequence alterations in ARID1B were identified in 5 of 72 patients (6.9%). Four of fiv ...[more]