Exploring public genomics data for population pharmacogenomics.
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ABSTRACT:
SUBMITTER: Lakiotaki K
PROVIDER: S-EPMC5542428 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Exploring public genomics data for population pharmacogenomics.
Lakiotaki Kleanthi K Kanterakis Alexandros A Kartsaki Evgenia E Katsila Theodora T Patrinos George P GP Potamias George G
PloS one 20170803 8
Racial and ethnic differences in drug responses are now well studied and documented. Pharmacogenomics research seeks to unravel the genetic underpinnings of inter-individual variability with the aim of tailored-made theranostics and therapeutics. Taking into account the differential expression of pharmacogenes coding for key metabolic enzymes and transporters that affect drug pharmacokinetics and pharmacodynamics, we advise that data interpretation and analysis need to occur in light of geograph ...[more]
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