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Mild Reductive Functionalization of Amides into N-Sulfonylformamidines.


ABSTRACT: The development of a protocol for the reductive functionalization of amides into N-sulfonylformamidines is reported. The one-pot procedure is based on a mild catalytic reduction of tertiary amides into the corresponding enamines by the use of Mo(CO)6 (molybdenum hexacarbonyl) and TMDS (1,1,3,3-tetramethyldisiloxane). The formed enamines were allowed to react with sulfonyl azides to give the target compounds in moderate to good yields.

SUBMITTER: Trillo P 

PROVIDER: S-EPMC5542752 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Mild Reductive Functionalization of Amides into <i>N</i>-Sulfonylformamidines.

Trillo Paz P   Slagbrand Tove T   Tinnis Fredrik F   Adolfsson Hans H  

ChemistryOpen 20170703 4


The development of a protocol for the reductive functionalization of amides into <i>N</i>-sulfonylformamidines is reported. The one-pot procedure is based on a mild catalytic reduction of tertiary amides into the corresponding enamines by the use of Mo(CO)<sub>6</sub> (molybdenum hexacarbonyl) and TMDS (1,1,3,3-tetramethyldisiloxane). The formed enamines were allowed to react with sulfonyl azides to give the target compounds in moderate to good yields. ...[more]

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