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Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients.

ABSTRACT: Carboxylesterase 1 (CES1) hydrolyzes the prodrug clopidogrel to an inactive carboxylic acid metabolite. The effects of CES1 S75N (rs2307240,C>T) on clopidogrel response among 851 acute coronary syndrome patients who came from the north, central and south of China were studied. The occurrence ratios of each endpoint in the CC group were significantly higher than in the CT?+?TT group for cerebrovascular events (14% vs 4.8%, p?

SUBMITTER: Xiao FY 

PROVIDER: S-EPMC5543069 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients.

Xiao Fei-Yan FY   Luo Jian-Quan JQ   Liu Min M   Chen Bi-Lian BL   Cao Shan S   Liu Zhao-Qian ZQ   Zhou Hong-Hao HH   Zhou Gan G   Zhang Wei W  

Scientific reports 20170803 1

Carboxylesterase 1 (CES1) hydrolyzes the prodrug clopidogrel to an inactive carboxylic acid metabolite. The effects of CES1 S75N (rs2307240,C>T) on clopidogrel response among 851 acute coronary syndrome patients who came from the north, central and south of China were studied. The occurrence ratios of each endpoint in the CC group were significantly higher than in the CT + TT group for cerebrovascular events (14% vs 4.8%, p < 0.001, OR = 0.31), acute myocardial infarction (15.1% vs 6.1%, p < 0.0  ...[more]