Ontology highlight
ABSTRACT:
SUBMITTER: Wang G
PROVIDER: S-EPMC5543139 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Wang Guodong G Liu Jun J Chen Ke K Xu Yiling Y Liu Bo B Liao Jie J Zhu Lei L Hu Xiaoxiao X Li Jianglin J Pu Ying Y Zhong Wen W Fu Ting T Liu Huixia H Tan Weihong W
Scientific reports 20170803 1
Excessive secretion of glucagon, a functional insulin antagonist, significantly contributes to hyperglycemia. Glucagon exerts its physiological functions through activation of the glucagon receptor (GCGR). Inhibition of GCGR activity represents a potential therapeutic approach for reducing excess glucose production in diabetes mellitus. Aptamers are short DNA or RNA oligonucleotides evolved from systematic evolution of ligands by exponential enrichment (SELEX). Here, we have successfully selecte ...[more]