Ontology highlight
ABSTRACT:
SUBMITTER: Nettore IC
PROVIDER: S-EPMC5543192 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Nettore Immacolata Cristina IC Albano Luigi L Ungaro Paola P Colao Annamaria A Macchia Paolo Emidio PE
Reviews in endocrine & metabolic disorders 20170901 3
Vitamin D exerts its canonical roles on the musculoskeletal system and in the calcium/phosphorus homeostasis. In the last years, increasing evidences suggested several extra-skeletal actions of this hormone, indicating that vitamin D may produce effects in almost all the body tissues. These are mediated by the presence of vitamin D receptor (VDR) and thanks to the presence of the 1-α-hydroxylase, the protein that converts the 25-hydroxyvitamin (calcidiol) to the active form 1,25-dihydroxyvitamin ...[more]