Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC5543303 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Zhang Sicai S Masuyer Geoffrey G Zhang Jie J Shen Yi Y Lundin Daniel D Henriksson Linda L Miyashita Shin-Ichiro SI Martínez-Carranza Markel M Dong Min M Stenmark Pål P
Nature communications 20170803
Botulinum neurotoxins are known to have seven serotypes (BoNT/A-G). Here we report a new BoNT serotype, tentatively named BoNT/X, which has the lowest sequence identity with other BoNTs and is not recognized by antisera against known BoNTs. Similar to BoNT/B/D/F/G, BoNT/X cleaves vesicle-associated membrane proteins (VAMP) 1, 2 and 3, but at a novel site (Arg66-Ala67 in VAMP2). Remarkably, BoNT/X is the only toxin that also cleaves non-canonical substrates VAMP4, VAMP5 and Ykt6. To validate its ...[more]