Genome-wide microRNA expression profiling in placentae from frozen-thawed blastocyst transfer.

ABSTRACT:

Background

Frozen-thawed embryo transfer (FET) is increasingly available for the improvement of the success rate of assisted reproductive technologies other than fresh embryo transfer (ET). There have been numerous findings that FET provides better obstetric and perinatal outcomes. However, the birth weight of infants conceived using FET is heavier than that of those conceived via ET. In addition, some reports have suggested that FET is associated with perinatal diseases such as placenta accreta and pregnancy-induced hypertension (PIH).

Results

In this study, we compared the microRNA (miRNA) expression profiles in term placentae derived from FET, ET, and spontaneous pregnancy (SP). We identified four miRNAs, miR-130a-3p, miR-149-5p, miR-423-5p, and miR-487b-3p, that were sig

SUBMITTER: Hiura H 

PROVIDER: S-EPMC5543431 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature