Ontology highlight
ABSTRACT:
SUBMITTER: Feng ZH
PROVIDER: S-EPMC5543468 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Feng Zi-Hao ZH Fang Yong Y Zhao Liang-Yun LY Lu Jun J Wang Yong-Qian YQ Chen Zhen-Hua ZH Huang Yong Y Wei Jin-Huan JH Liang Yan-Ping YP Cen Jun-Jie JJ Pan Yi-Hui YH Liao Bing B Chen Wei W Luo Jun-Hang JH
Cancer science 20170703 8
We previously identified the important role of RIN1 expression in the prognosis of clear cell renal cell carcinoma (ccRCC). The role of RIN1 in ccRCC malignancy and underlying molecular mechanisms remain unclear. Here we report that ccRCC cells and tissues expressed more RIN1 than normal controls. Gain-of-function and loss-of-function studies demonstrated that RIN1 enhanced ccRCC cell growth, migration and invasion abilities in vitro and promoted tumor growth and metastasis in vivo. Mechanistic ...[more]